| 1619 | Virginia assembly, called House of Burgesses, meets for the first time |
| 1620 | Pilgrims sign the Mayflower Compact |
| 1630 | John Winthrop transfers Massachusetts Bay charter to New England |
| 1676 | Bacon's Rebellion threatens Governor Berkeley's government in Virginia |
| 1689 | Rebellions break out in Massachusetts, New York, and Maryland |
| 1754 | Albany Congress meets |
| 1772 | Samuel Adams forms committee of correspondence |
| 1774 | Parliament punishes Boston with Coercive Acts (March-June), First Continental Congress convenes (September) |
| 1775 | Second Continental Congress gathers (May) |
| 1776 | Congress votes for independence; Declaration of Independence is signed |
| 1783 | Newburgh Conspiracy thwarted (March) |
| 1789 | George Washington inaugurated (April) |
| 1793 | Spread of “Democratic” Clubs alarms Federalists, Jefferson resigns as secretary of state (December) |
| 1794 | Whiskey Rebellion put down by U.S. Army (July-November) |
| 1795 | Hamilton resigns as secretary of the treasury (January) |
| 1796 | Washington publishes “Farewell Address” (September), John Adams elected president (December) |
| 1798 | Congress passes the Alien and Sedition Acts (June and July), Virginia and Kentucky Resolutions protest the Alien and Sedition Acts (November and December) |
| 1801 | House of Representatives elects Thomas Jefferson president (February), Adams makes “midnight” appointments of federal judges |
| 1804 | Aaron Burr kills Alexander Hamilton in a duel (July), Jefferson elected to second term |
| 1805 | Justice Samuel Chase acquitted by Senate (March) |
| 1807 | Burr is tried for conspiracy (August-September) |
| 1808 | Madison elected president |
| 1812 | Madison elected to second term, defeating De Witt Clinton of New York |
| 1816 | James Monroe elected president |
| 1820 | Monroe reelected president unanimously |
| 1824 | House of Representatives elects John Quincy Adams president |
| 1828 | Jackson elected president over J. Q. Adams |
| 1831 | Jackson reorganizes his cabinet, First national nominating conventions meet |
| 1832 | Jackson reelected, defeating Henry Clay (National Republican candidate) |
| 1834 | Whig party comes into existence |
| 1836 | Martin Van Buren elected president |
| 1840 | Harrison (Whig) defeats Van Buren (Democrat) for the presidency |
| 1841 | President John Tyler inaugurated |
| 1844 | James K. Polk elected president on a platform of expansionism |
| 1848 | Free-Soil party is founded, Zachary Taylor (Whig) elected president, defeating Lewis Cass (Democrat) and Martin Van Buren (Free-Soil) |
| 1852 | Franklin Pierce (Democrat) elected president by a large majority over Winfield Scott (Whig) |
| 1854 | Republican party founded in several northern states |
| 1854-1855 | Know-Nothing party achieves stunning successes in state politics |
| 1856 | Preston Brooks assaults Charles Sumner on Senate floor; James Buchanan wins presidency despite strong challenge in the North from John C. Fremont |
| 1858 | Lincoln and Douglas debate slavery issue in Illinois |
| 1859-1860 | Fierce struggle takes place over election of a Republican as Speaker of the House (December-February) |
| 1861 | Republicans nominate Abraham Lincoln for presidency (May), Democratic party splits into northern and southern factions with separate, candidates and platforms (June), Lincoln wins the presidency over Douglas, Breckinridge, and Bell |
| 1863 | Lincoln is reelected president, defeating McClellan (November) |
| 1863 | Lincoln sets forth 10 percent Reconstruction plan |
| 1864 | Wade-Davis Bill passes Congress but is pocket vetoed by Lincoln |
| 1865 | Lincoln assassinated by John Wilkes Booth (April) |
| 1865 | Johnson moves to reconstruct the South on his own initiative, Congress refuses to seat representatives and senators elected from states reestablished under presidential plan (December) |
| 1866 | Johnson vetoes Freedmen's Bureau Bill (February), Republicans increase their congressional majority in the fall elections |
| 1867 | First Reconstruction Act is passed over Johnson's veto (March) |
| 1868 | Johnson is impeached, he avoids conviction by one vote (February-May), Grant wins presidential election, defeating Horatio Seymour |
| 1872 | Grant reelected president, defeating Horace Greeley, candidate of Liberal Republicans and Democrats |
| 1875 | "Whiskey Ring" scandal exposed |
| 1876-1877 | Disputed presidential election resolved in favor of Republican Hayes over Democrat Tilden |
| 1880 | Republican James A. Garfield elected president |
| 1881 | Garfield assassinated; Vice President Chester A. Arthur becomes president |
| 1884 | Democrat Grover Cleveland elected president, defeating Republican James G. Blaine |
| 1888 | Republican Benjamin Harrison wins presidential election |
| 1890 | Republican-dominated “Billion-Dollar” Congress enacts McKinley Tariff Act, Sherman Antitrust Act, and Sherman Silver Purchase Act, Farmers' Alliance adopts the Ocala Demands |
| 1892 | Democrat Cleveland defeats Republican Harrison for presidency, People's Party formed |
| 1896 | Republican McKinley defeats William Jennings Bryan, Democratic and Populist candidate, in "Battle of the Standards" |
| 1900 | McKinley reelected, again defeating Bryan; Galveston, Texas, is first city to try commission form of government |
| 1901 | McKinley assassinated, Vice President Theodore Roosevelt assumes presidency, Robert M. La Follette elected reform governor of Wisconsin, Socialist party of America organized |
| 1902 | Oregon adopts the initiative and referendum |
| 1904 | Roosevelt elected president |
| 1908 | Taft elected president, |
| 1909 | Payne-Aldrich Tariff Act divides Republican party |
| 1910 | Taft fires Gifford Pinchot, head of U.S. Forest Service, 1910 Democrats sweep midterm elections |
| 1912 | Progressive party formed, nominates Roosevelt for president; Woodrow Wilson elected president |
| 1916 | Wilson wins reelection |
| 1920 | Warren G. Harding elected president |
| 1924 | Senate probes Teapot Dome scandal, Veterans' World War I bonus bill passed |
| 1932 | Franklin D. Roosevelt elected president |
| 1936 | FDR wins second term as president |
| 1937 | FDR loses court-packing battle (July) |
| 1945 | FDR dies, Harry Truman becomes president (April) |
| 1946 | Republicans win control of both houses of Congress in November elections |
| 1948 | Truman scores upset victory in presidential election |
| 1952 | Dwight D. Eisenhower elected president |
| 1963 | JFK assassinated; Lyndon B. Johnson sworn in as president (November) |
| 1964 | Johnson wins presidency in landslide (November) |
| 1968 | Johnson announces he will not seek reelection (March) |
| 1968 | Robert Kennedy assassinated in Los Angeles (June) |
| 1972 | White House “plumbers” unit breaks into Democratic headquarters in Watergate complex (June), Richard Nixon wins reelection in landslide victory over McGovern (November) |
| 1974 | Supreme Court orders Nixon to surrender White House tapes (June); Richard M. Nixon resigns presidency (August) |
| 1976 | Jimmy Carter defeats Gerald Ford in presidential election (November) |
| 1980 | Ronald Reagan wins presidency in landslide |
| 1984 | Ronald Reagan reelected president (November) |
| 1988 | George Bush defeats Michael Dukakis decisively in presidential election |
| 1991 | Bush breaks "no new taxes” campaign pledge, supports $500 billion budget deal (November) |