| 1481 | Portuguese build castle at Elmina on the Gold Coast of Africa |
| 1619 | First slaves sold at Jamestown |
| 1739 | Stono Uprising of South Carolina slaves terrifies white planters |
| 1800 | Gabriel Prosser leads abortive slave rebellion in Virginia |
| 1808 | Slave trade is ended (January) |
| 1811 | Slaves revolt in Point Coupee section of Louisiana |
| 1822 | Denmark Vesey conspiracy uncovered in Charleston, South Carolina |
| 1829 | David Walker publishes Appeal calling for slave insurrection |
| 1830 | First National Negro Convention meets |
| 1831 | Slaves under Nat Turner rebel in Virginia, killing almost sixty whites |
| 1832 | Virginia legislature votes against gradual emancipation |
| 1835-1842 | Blacks fight alongside Indians in the Second Seminole War |
| 1846 | David Wilmot introduces proviso banning slavery in the Mexican cession |
| 1850 | Congress debates sectional issues and enacts Compromise of 1850 |
| 1851 | Group of free blacks rescues escaped slave Shadrack from federal authorities in Boston |
| 1854 | Congress passes Kansas-Nebraska Act, repealing Missouri Compromise |
| 1857 | Hinton R. Helper attacks slavery on economic grounds in The Impending Crisis of the South; the book is suppressed in the southern states |
| 1857 | Supreme Court decides Dred Scott case and legalizes slavery in all territories |
| 1862 | Lincoln issues preliminary Emancipation Proclamation (September) |
| 1863 | Lincoln issues final Emancipation Proclamation (January) |
| 1865 | Congress passes Thirteenth Amendment abolishing slavery (January) |
| 1866 | Johnson vetoes Civil Rights Act, it passes over his veto (April), Congress passes Fourteenth Amendment (June) |
| 1896 | Supreme Court decision in Plessy v. Ferguson establishes constitutionality of "separate but equal" facilities |